Analytical Toxicology - Research Groups

Group in Geneva

Analytical developments (Jean-Luc Veuthey, Serge Rudaz, Davy Guillarme, co-applicants)

The laboratory of pharmaceutical analytical chemistry (LCAP) is mainly involved into the development of liquid chromatography (LC) and capillary electrophoresis (CE) for the analysis of drugs and metabolites in biological matrices. The LCAP has already developed different methods for the rapid and cheap analysis of drugs [79-82] by CE and LC in different matrices as biological matrices [83,84]. The LCAP has also developed new tools for the rapid on-line digestion of proteins. Indeed, the growing interest in proteomics such as detection of pathological changes in proteins, detection of post-translational modification and quality control of recombinant proteins induces the development of robust, automated, sensitive and high-throughput analytical tools. IMER (immobilized enzyme reactor) allowing a rapid protein digestion (min instead of hours) is cost-effective and compatible with high throughput procedures for the rapid on-line protein digestion and peptide analysis by LC-MS-MS [85,86].

Last Updated on Thursday, 25 March 2010 15:36 Created: Thursday, 02 April 2009 09:01