Immunotoxicology - Research Groups

Immunotoxicology (Werner Pichler, co-applicant)
This research group is currently one of the leading groups in immunotoxicology in Europe. A special research focus is placed on drug- associated hypersensitivity syndromes, where the group made major contributions to the understanding of the mechanisms and classification of the disease (24b). The group proposed the p-i-concept, stating that direct activation of the T cell receptor by drugs is possible (no hapten formation is needed) (24c). Recent research shows that direct T cell receptor activation is probably one of the most important mechanisms of drug-associated hypersensitivity. Based on this concept, the group is trying to establish cellular systems for screening the allergenic potential of new drugs or drug candidates (24d).  

Last Updated on Thursday, 25 March 2010 15:38 Created: Thursday, 02 April 2009 15:25